While the pursuit of hedonism is legitimated by neoliberal governmentality, its disciplining and isolating forces prevent individuals from being fulfilled by their pursuit of pleasure. Concomitantly, this hedonism (pursuing pleasure to avoid pain) causes individuals to withdraw from public political life. In this article we argue that, instead of attempting to pursue pleasure through the experience of material comfort, individuals ought to orient themselves towards membership in substantive political associations. Further, we argue that it is through such membership that one (...) can attain genuine fulfilment, while simultaneously reclaiming agency, both on individual and collective terms. Though individuals must be willing to take on the risk of pain, their membership in substantive political associations provides genuine fulfilment, while also allowing for the construction of new worlds through political action. (shrink)

Theoretical frameworks concerning cell fate typically center on proximate causes to explain how cells know what type they are meant to become. While major advances in cell fate theory have been achieved by these mechanism-focused frameworks, there are some aspects of cell decision-making that require an evolutionary interpretation. While mechanistic biologists sometimes turn to evolutionary theory to gain insights about cell fate (cancer is a good example), it is not entirely clear in cell fate theory what insights evolutionary theory can (...) add, and why in some cases it is required for understanding cell fate. In this perspective we draw on our work on cellular mortality to illustrate how evolutionary theory provides an explanation for death being selected as one of the potential cell fates. Using our hypothesis for why some microbes in a community choose death as their fate, we suggest that some insights in cell fate theory are inaccessible to a theoretical framework that focuses solely on proximate causes. (shrink)

Organismal death is foundational to the evolution of life, and many biological concepts such as natural selection and life history strategy are so fashioned only because individuals are mortal. Organisms, irrespective of their organization, are composed of basic functional units—cells—and it is our understanding of cell death that lies at the heart of most general explanatory frameworks for organismal mortality. Cell death can be exogenous, arising from transmissible diseases, predation, or other misfortunes, but there are also endogenous forms of death (...) that are sometimes the result of adaptive evolution. These endogenous forms of death—often labeled programmed cell death, PCD—originated in the earliest cells and are maintained across the tree of life. Here, we consider two problematic issues related to PCD (and cell mortality generally). First, we trace the original discoveries of cell death from the nineteenth century and place current conceptions of PCD in their historical context. Revisions of our understanding of PCD demand a reassessment of its origin. Our second aim is thus to structure the proposed origin explanations of PCD into coherent arguments. In our analysis we argue for the evolutionary concept of PCD and the viral defense-immunity hypothesis for the origin of PCD. We suggest that this framework offers a plausible account of PCD early in the history of life, and also provides an epistemic basis for the future development of a general evolutionary account of mortality. (shrink)

In multicellular organisms, cells are frequently programmed to die. This makes good sense: cells that fail to, or are no longer playing important roles are eliminated. From the cell’s perspective, this also makes sense, since somatic cells in multicellular organisms require the cooperation of clonal relatives. In unicellular organisms, however, programmed cell death poses a difficult and unresolved evolutionary problem. The empirical evidence for PCD in diverse microbial taxa has spurred debates about what precisely PCD means in the case of (...) unicellular organisms. In this article, we survey the concepts of PCD in the literature and the selective pressures associated with its evolution. We show that definitions of PCD have been almost entirely mechanistic and fail to separate questions concerning what PCD fundamentally is from questions about the kinds of mechanisms that realize PCD. We conclude that an evolutionary definition is best able to distinguish PCD from closely related phenomena. Specifically, we define “true” PCD as an adaptation for death triggered by abiotic or biotic environmental stresses. True PCD is thus not only an evolutionary product but must also have been a target of selection. Apparent PCD resulting from pleiotropy, genetic drift, or trade-offs is not true PCD. We call this “ersatz PCD.”. (shrink)

This collection examines prevalent assumptions in moral reasoning which are often accepted uncritically in medical ethics. It introduces a range of perspectives from philosophy and medicine on the nature of moral reasoning and relates these to illustrative problems, such as New Reproductive Technologies, the treatment of sick children, the assessment of quality of life, genetics, involuntary psychiatric treatment and abortion. In each case, the contributors address the nature and worth of the moral theories involved in discussions of the relevant issues, (...) and focus on the types of reasoning which are employed. 'Medical ethics is in danger of becoming a subject kept afloat by a series of platitudes about respect for persons or the importance of autonomy. This book is a bold and imaginative attempt to break away from such rhetoric into genuine informative dialogue between philosophers and doctors, with no search after consensus.' Mary Warnock. (shrink)

The classical theory of preference among monetary bets represents people as expected utility maximizers with concave utility functions. Critics of this account often rely on assumptions about preferences over wide ranges of total wealth. We derive a prediction of the theory that bears on bets at any fixed level of wealth, and test the prediction behaviorally. Our results are discrepant with the classical account. Competing theories are also examined in light of our data.

Attentional control has grown in importance within theoretical and predictive models of psychopathology over past decades. The Attentional Style Questionnaire is a novel measure of internal a...

A judgement analysis of people's social inferences of attitudes and ability was conducted. University students were asked to infer the liberalness ( N = 60; Study 1) or intelligence ( N = 40; Study 2) of targets seen in pictures. Multiple regression analyses revealed that attractiveness was the most important cue for predicting inferences of liberalness, while an ethnic cue (i.e., being Asian) was the most important cue for judgements about intelligence. Results also showed that a single-cue model was less (...) susceptible to overfitting, but significantly less accurate than a multiple-cue model in predicting participant's intelligence judgements. Although the multiple regression models suffered a degree of overfitting, cross validation showed that they continued to have significant predictive value when applied to new data. Furthermore, a “random partner” method (comparing each participant's own regression equation with that of another, randomly selected, participant) provided evidence of significant idiosyncratic variation in the way intelligence judgements were made. (shrink)

In the human quest for meaning, work occupies a central position. Most adults spend the majority of their waking hours at work, which often serves as a primary source of purpose, belongingness, and identity. In light of these benefits to employees and their organizations, organizational scholars are increasingly interested in understanding the factors that contribute to meaningful work, such as the design of jobs, interpersonal relationships, and organizational missions and cultures. In a separate line of inquiry, scholars of business ethics (...) have examined meaningful work as a moral issue concerning the management of others and ourselves, exploring whether there are definable characteristics of meaningful work to which we have moral rights, and whether there are moral duties to ourselves and others to fulfill those rights. In this article, we examine contemporary developments in both disciplines about the nature, causes, and consequences of meaningful work; we explore linkages between these disciplines; and we offer conclusions and research opportunities regarding the interface of ethical and organizational perspectives on performing and providing meaningful work. (shrink)

Serial music was one of the most important aesthetic movements to emerge in post-war Europe, but its uncompromising music and modernist aesthetic has often been misunderstood. This book focuses on the controversial journal die Reihe, whose major contributors included Stockhausen, Eimert, Pousseur, Dieter Schnebel and G. M. Koenig, and discusses it in connection with many lesser-known sources in German musicology. It traces serialism's debt to the theories of Klee and Mondrian, and its relationship to developments in concrete art, modern poetry (...) and the information aesthetics and semiotics of Max Bense and Umberto Eco. M. J. Grant sketches an aesthetic theory of serialism as experimental music, arguing that serial theory's embrace of both rigorous intellectualism and aleatoric processes is not, as many have suggested, a paradox, but the key to serial thought and to its relevance for contemporary theory. (shrink)

Seen in its historical context, Mazur & Booth's (M&B's) target article may come to be viewed as a turning point in the study of the biological basis of human behavior in general, and dominance in particular. To facilitate further research, suggestions are offered for making the definition of dominance more precise. From an evolutionary point of view, the testosterone-dominance link may be as important in women as it is in men.

In this important new study, Hamilton establishes and develops innovative links between the sites of postcolonial literary theory, the fiction of the South African/Australian academic and Nobel Prize-winning writer J.M. Coetzee, and the work of the French poststructuralist philosopher Gilles Deleuze. Centering on the key postcolonial problematic of representation, Hamilton argues that if one approaches the colonial subject through Gilles Deleuze’s rewriting of subjectivity, then a transcendent configuration of the colonial subject is revealed. Importantly, it is this rendition of the (...) colonial subject that accounts best for the way in which the colonial subject is able to propose and offer instances of resistance to colonial structures of subjectification. In elucidating this claim, the study turns to the fiction of Coetzee. Offering unique Deleuzean readings of three of Coetzee’s most theoretically beguiling novels – Dusklands, Waiting for the Barbarians, and Foe – On Representation will prove to be essential reading to those interested in Coetzee studies, the literary terrain of Deleuze’s philosophy, and those engaging with contemporary debates in postcolonial literature and theory. (shrink)

This is an interview with author Lester Grinspoon, M.D., whose work on psychoactive substances over the last thirty‐five years has been highly influential. His book, Marihuana: The Forbidden Medicine (written with James B. Bakalar), is a classic source on the medical marijuana controversy. His books Psychedelic Drugs Reconsidered and Cocaine: A Drug and Its Social Evolution are standards in the field. Dr. Grinspoon received his M.D. from Harvard Medical School and currently is associate professor emeritus at Harvard Medical School. His (...) academic work has also reached a general audience through publications ranging from the New York Times Book Review to Playboy. Describing him as the "complete medical scholar," his citation for the Lindesmith Award for Achievement in the Field of Scholarship also notes, "Lester Grinspoon represents all those scholars who report the results of their research truthfully, despite the political consequences of this unwelcomed honesty.". (shrink)

A veritable cookbook for individuals or corporations seeking funding from the federal government, The Complete Writing Guide to NIH Behavioral Science Grants contains the latest in technical information on NIH grants, including the new electronic submission process. Some of the most successful grant writers in history have contributed to this volume, offering key strategies as well as tips and suggestions in areas that are normally hard to find in grant writing guides, such as budgeting, human subjects, and power (...) analysis. A "who's who" among grant reviewers, this guidebook provides "inside" information as to why some grants are scored well while others flounder during review. A must-read for both entry level grant writers making headway in the complex NIH grant system for the first time as well as more seasoned investigators who can't seem to break the barrier to funded research grants, Drs. Scheier and Dewey's comprehensive volume provides simple and clear explanations into the reasons why some grants get funded, and a step-by-step guide to writing those grants. (shrink)

People with lived experience are individuals who have first-hand experience of the medical condition being considered. The value of including the viewpoints of people with lived experience in health policy, health care, and health care and systems research has been recognized at many levels, including by funding agencies. However, there is little guidance or established best practices on how to include non-academic reviewers in the grant review process. Here we describe our approach to the inclusion of people with lived (...) experience in every stage of the grant review process. After a budget was created for a specific call, a steering committee was created. This group included researchers, people with lived experience, and health systems administrators. This group developed and issued the call. After receiving proposals, stage one was scientific review by researchers. Grants were ranked by this score and a short list then reviewed by people with lived experience as stage two. Finally, for stage three, the Steering Committee convened and achieved consensus based on information drawn from stages one and two. Our approach to engage people with lived experience in the grant review process was positively reviewed by everyone involved, as it allowed for patient perspectives to be truly integrated. However, it does lengthen the review process. The proposed model offers further practical insight into including people with lived experience in the review process. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:542 BOOK REVIEWS Forty years later, Pope Pius XI realized the atfaimpts of some writers to attribute the Church's social teaching on property to spurious sources when he wrote: Let this be noted particularly by those seekers after novelties who launch against the Church the odious calumny that she has allowed a pagan concept of ownership to creep into the teachings of her theologians and that another concept must (...) be substituted, which in their astounding ignorance they call ' Christian ' (Quadragesimo Anno 46). Benedictine College.Atchison, Kansas MATTHEW HABIGER, 0.S.B. Gods and the One God. By ROBERT M. GRANT. Vol. 1 of the Library of Early Christianity (Wayne A. Meeks, General Editor). Philadelphia : Westminster Press, 1986. Pp. 211. $18.95. No one is more qualified that Robert M. Grant to discuss the relations between early Christianity and ifa classieal environment. As, the author of two important introductions to the New Testament,.Augustus to Constantine, The Early Christian Doctrine of God, Early Christianity and Society, Gnosticism and Early Christianity, and much more, Grant brings the fruits of a lifetime of scholarship to his task. It is cause for special rejoicing that he has produced a book which the beginning student as well as the specialized scholar can read. In this review I want to raise some questions and make some criticisms, but let it be clear a,t the outset that this is an important and valuable book. Beginning with a discussion of the references to pagan religion in the Book of Acts, Grant then surveys how, around the time of Christ, many gods were moving from the East to Rome. A third chapter looks at attacks on idolatry in the New Testament and other early Christian texts. That analysis leads into discussions of the functions and myths of various classical deities and the philosophical views of God in the ancient world. Finally, a series of chapters begins with the Christian doctrine of God and then traces the dev,elopment of Christology from its beginnings through several centuries (with special emphasis on how that development took shape in Antioch) to the culminating formulation of the doctrine of the Trinity. Grant has always written in a spare, clean style most scholars can only envy; this is one of the reasons for the popularity in the classroom of his BOOK REVIEWS 548 introductions to the New Testament. That style makes this work suitable even for beginning s.tudents, though attention to such an audience's background seems uneven. For example, Justin Martyr gets clearly introduced: " The first significant Christian apologist was Justin Martyr, who wrote at Rome around the year 150" (p. 87). But two pages earlier we were suddenly reading about Philo without any sueh introduction, without even locating him in Alexandria. Again, one passage concludes with the statement that, "in the second and third centuries, all ran the risk of dynamistic or modalistic l\fonarchianism " (p. 111), and another refers to " a Spanish Priscillianist" (p. 151), but such terms are never defined. Theologically oriented readers may grow impatient with some chapters. Grant has the hisforian's passion for the clearly established fact. Thus his second chapter sets out at some length the evidence for the date of the first worship in or near Rome of the Baal of Sarepta, Asclepius, the Great Mother, Isis, Serapis, Dionysius, Mithras, and the God of Israel. Later on (pp. 114ff), Grant shows how many deities, not just Zeus, could take on the attributes of cosmic creator-the case is made for Apollo, Athena, Dionysius, Hermes, and Isis. In both cases, examples seem multiplied past the point where we learn anything of more than antiquarian importance. On the other hand, the survey of Greek philosophy begins with the pre-Socratics and then puzzlingly skips to the pseudo-Aristotelian On the Heavens and the writings of the middle Platonists. Appeals by others to Plato appear again and again in later chapters, but no.t an account of Plato's own views. Greek philosophy without Plato and Aristotle does seem a bit like Hamlet without the prince of Denmark. Useful as Grant's surveys are, moreover, the early chapters lack the overarching vision of Charles Cochrane... (shrink)

Clinicians' work depends on sincere and complete disclosures from their patients; they honour this candidness by confidentially safeguarding the information received. Breaching confidentiality causes harms that are not commensurable with the possible benefits gained. Limitations or exceptions put on confidentiality would destroy it, for the confider would become suspicious and un-co-operative, the confidant would become untrustworthy and the whole climate of the clinical encounter would suffer irreversible erosion. Excusing breaches of confidence on grounds of superior moral values introduces arbitrariness and (...) ethical unreliability into the medical context. Physicians who breach the agreement of confidentiality are being unfair, thus opening the way for, and becoming vulnerable to, the morally obtuse conduct of others. Confidentiality should not be seen as the cosy but dispensable atmosphere of clinical settings; rather, it constitutes a guarantee of fairness in medical actions. Possible perils that might accrue to society are no greater than those accepted when granting inviolable custody of information to priests, lawyers and bankers. To jeopardize the integrity of confidential medical relationships is too high a price to pay for the hypothetical benefits this might bring to the prevailing social order. (shrink)

There are two conspicuous and inescapable features of this world in which time is real. One experiences a world in flux, a transient world in which things constantly come into existence, change and cease to be. One also experiences a stable world, one in which how things are at any given moment is permanent, unchangeable. Thus, there is transience and permanence. Yet these two features of the world seem incompatible. The primary purpose of this paper is to sketch a metaphysics (...) of time that embraces both features. Crucial to this undertaking is the notion of becoming, that is, coming into existence. I distinguish three distinct phenomena of becoming: temporal, absolute and atemporal. The last is the least familiar of these; it is the phenomenon of coming into existence outside of time. Although the idea that there are things that do not exist in time is not unfamiliar, it is largely taken for granted that if anything comes into existence, it must do so in time. (Indeed, I suspect many think that the idea of a thing coming to be outside of time is simply incoherent.) In this paper, I articulate and defend the notion of atemporal becoming. It is by means of this notion that one can develop a fully satisfactory metaphysics of time, one that honors both transience and permanence and finds for each its proper domain within the world. (shrink)

Parental decision making is necessary for contracting medical interventions that require personal risk–benefit evaluation, and for overseeing matters of education. In the nineteenth century, exemptions from obligatory vaccination were granted for religious and conscientious reasons. Then and today, religion and moral values play marginal roles in vaccine hesitancy and denialism. Rather, the key values invoked by vaccine hesitants and denialists are liberty and pluralism. Neither is compatible with limiting adolescents’ choice. Because vaccination does not require assessment of personal medical risks, (...) because it does not need to occur within the sphere of the doctor–patient relationship, and because the risk involved is within the range of their daily activities, adolescents have the right to free access to vaccination without legal requirement of parental involvement. Drawing on the development of Common Law, and on the development of respect for personal conscience in the history of ideas, this paper does not promote an argument that grants public health an overriding moral power. Rather, this paper rejects the presumption that vaccination of adolescents might involve a conflict between parental authority and public health. Free access to vaccination is compatible with the law and ethics of adolescents’ evolving autonomy in relation to healthcare. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Mystery of Problems for Modern Theological MethodologyBruno M. Shah O.P.Recent trends in Catholic theology emphasize the category of "mystery." But "problems," which can seem distinct from and even opposed to mysteries, have a constitutive role in the work of theology as well. If the object of faith is God, and if theology's goal is typically defined as "faith seeking understanding," then the object of theology must include the (...) seeking's problematical quotient. At the very least, problems condition the faith-and-reason labor of theological enquiry. This essay claims that problems philosophically orient and index the theological articulation of mysteries—not the mysteries themselves—particularly in a modern key, and that they require explicit attention in theological methodology and pedagogy.First, I explain my concern with the "return to mystery" in conciliar-era Catholic theology. This explanation entails, second, describing the special attention to "problems" in neo-Kantianism, which bequeaths the tension between the empirical world and transcendental freedom to modern theology. These two historiographical matters in methodology set up the tension between problems and mysteries for Catholic thinking. Third, I briefly return to Aristotle's thoughts on the matter, which are a lodestone for the tradition. Fourth, I evaluate the positions of Jacques Maritain and Gabriel Marcel, the most important conciliar-era thinkers who thematized the relationship between problems and mysteries. My treatment will show how both ontological (Maritain) and existential (Marcel) dynamics of mystery are necessarily linked to metaphysical and spiritual problems. The [End Page 1265] critical ascertaining of theological mystery formally requires orientation via philosophical problems.My concern here is fundamental, ecclesial, and professional, interested that those who serve the Church through theological writing and teaching do so in a recognizably common or compatible manner, and in a way that can meaningfully stimulate theological interest. If the teaching of theology would invite students to embark upon the via inventionis and not merely yield to the via doctrinae, there must be fundamental advertence to ontological and existential problems as the theologically constitutive point of departure.1 Theologians do well to think in correlative terms of problems and mysteries. As a fifth and final point, then, I suggest that the quintessential starting point for (fundamental) theology today is the problem and mystery of the human person.Historical Context 1: The Return to MysteryContemporary Church life and theology have witnessed a "return to mystery."2 "Mystery" refers to some range or dynamic of reality that is essentially inaccessible apart from some feature of religious or spiritual practice. Christian reference to "mystery" or "mysteries" etymologically intimates that there are realities of which we cannot and/or ought not to speak, even as these mysteries have in some way been disclosed.3 Mysteries, therefore, are tensional in that they indicate at once contact and transcendence, knowledge and nescience. Christians and others communicate in religious mysteries through liturgical exercise and creedal confession, as well as through personal prayer and even existential trial. They are mediations of what is categorically transcendent, of what constitutively eludes or escapes [End Page 1266] the categories of our objectifying consciousness. Accordingly, the mysterious regards the inarticulable.That the substance of religious mysteries is real or true cannot be proven beyond all question, not according to commonly accessible human criteria of justification. For Christians, the gift of faith provides the convincing motive to believe in the reality of Christian mysteries through a kind of thinking with felt decision. Granting this claim, the work of theology is to reflect upon the mysteries of faith and develop expressible knowledge. Theology articulates (the) faith, extrapolating upon the reasons that the heart has for its belief. To do this work, theology trades upon fixed standards of confessional speech, liturgical practice, and perhaps also moral action, which provide lexical cogency and communicable intelligibility.The late nineteenth century witnessed attacks upon theology's claims to objectively or universally valid expression, owing especially to challenges from both epistemology and historiography.4 The surge of post-Enlightenment liberalism was surely catalytic as well. The Catholic Church initially aggregated these attacks in terms of "modernism." But then—as the standard history continues—conciliar theology gave fresh and viable riposte to what was... (shrink)

Channeling affinities with certain motifs of Daoism, Walter Benjamin renews a form of dialectical thought that diffuses ideological notions of progress and grants minimal weight to the ontological distinction of the Subject. In fleeting yet pivotal moments of contact with Chinese aesthetics, Benjamin moves attention toward the practice of ‘thinking by way of resemblance’ – a phenomenon he variously enacts. Calling forth resonances within late-capitalist modernity, he retrieves from Daoist literature a notion of dialectical reversal freed from progressive synthesis, as (...) well as image-repertoires of self-forgetting, which he understands to be irreducible to reification. The Daoist imaginary offers Benjamin resources for breaking open the anthropocentric closure of Hellenic accounts of mimesis. He theorizes similitude more capaciously as something that can flash up across temporally discontinuous phenomena – without deferring to predetermined categories of Being. Benjamin thus recasts resemblance – regarded by Enlightenment rationality as an impoverished mode of cognition – as a medium of historical apprehension that resists the occlusion of transience by the ontology of the victors. (shrink)

Supererogatory acts are considered by some to be part of medicine, whereas others accept supererogation to be a gratuitous virtue, to be extolled when present, but not to be demanded. The present paper sides with those contending that medicine is duty-bound to benefit patients and that supererogation/altruism must per definition remain outside and beyond any role-description of the profession. Medical ethics should be bound by rational ethics and steer away from separatist views which grant exclusive privileges but also create (...) excessive demands, way beyond what physicians perform or are willing and able to offer. (shrink)

The development of cancer therapies is a long and arduous process. Because it can take several years for a cancer agent to pass clinical testing and be approved for use, terminal cancer patients rarely have the time to see these experimental therapies become widely available. For most terminal cancer patients the only opportunity they have to access an experimental drug that could potentially improve their prognosis is by joining a clinical trial. Unfortunately, several aspects of clinical trial methodology that are (...) set in place in order to optimise drug development for the benefit of future generations of cancer patients, pose significant limitations to current patient participation. Therefore, several terminal cancer patients believe that they should have the right to access experimental agents that have passed initial safety testing without having to participate in clinical trials. However, granting off-trial access to patients could be detrimental to the scientific process of drug development, and thus could pose significant risks to the health of future patients relying on sound research. Examining this matter through two divergent ethical lenses, rights-based ethics and communitarian ethics, may provide new insight into the issues surrounding the balance between the autonomous rights of current terminal cancer patients, and the needs of future patients and the values of society. (shrink)

Based on detailed descriptions of human–machine ensembles, this article explores how humans and machines work together to see specific things and unsee others, and how they come to co-configure one another. For seeing is not an automated function; whether one is a human or a machine, vision is gradually enskilled and mutually co-constituted. The analysis intersects three different ways of human–machine seeing to shed further light on the workings of each one: an airport, where facial recognition algorithms collaborate with border (...) guards to grant passage to particular travellers and not to others; a luggage-scanning system, where potential security threats are assessed by a complex of X-rays and human intro-spection; and a hospital operating room, where human–machinic surgical robots find their way and operate on the insides of human bodies, touching only by seeing. In these examples, human and machine ways of seeing merge together, seeing in particular apparatuses of material, political, organisational, economic and fleshy components. The article analyses the practical work of human–machinic collaboration and explores how the different material and social constituents, not necessarily always working from the same agenda, come to configure what can be seen and sensed and what cannot. (shrink)

The paper tries to analyze critically what is usually taken for granted – the causal relation between empirical knowledge about external world and the world which is (supposedly) known. The aim is neither to propose a new definition of knowledge nor to restate an old one but rather to take a closer look at the claim that knowledge is a true belief caused in a proper way by facts, events, etc. of the external world. This claim is a core of (...) the epistemological approach usually labeled as “causal theory of knowledge”, but there are many causal theories distinct from each other. The paper therefore sketches the causal components of D. Davidson’s epistemology and the roles they play in the process of cognizing, first. Then it exposes more details of Davidson’s approach and pushes some of them further critically. (shrink)

We present a derivation of the third postulate of relational quantum mechanics from the properties of conditional probabilities. The first two RQM postulates are based on the information that can be extracted from interaction of different systems, and the third postulate defines the properties of the probability function. Here we demonstrate that from a rigorous definition of the conditional probability for the possible outcomes of different measurements, the third postulate is unnecessary and the Born’s rule naturally emerges from the first (...) two postulates by applying the Gleason’s theorem. We demonstrate in addition that the probability function is uniquely defined for classical and quantum phenomena. The presence or not of interference terms is demonstrated to be related to the precise formulation of the conditional probability where distributive property on its arguments cannot be taken for granted. In the particular case of Young’s slits experiment, the two possible argument formulations correspond to the possibility or not to determine the particle passage through a particular path. (shrink)

How can one make sense of our current political, ecological and technological dilemmas through the lens of Grant Sputore’s I Am Mother (2019)? Well-received, the film has been commended for its account of the increasing role and impact of artificial intelligence and its relation to our ongoing ecological dilemmas and potential catastrophe. While these issues are played-out through the on-screen relationship between robotic mother and human daughter, the film can also be used to help shed light on our current (...) ideological predicaments. With a narrative that steers towards our preference for cynical detachment, apathy and resignation, this review draws upon Lacan’s notion of the big Other, and its relation to the subject, in order to provide further discussion on the film’s ambiguous ending and the deeper sense of impotence that it accurately portrays with regards to our current political malaise. (shrink)

Given the tremendous burst of activity in the philosophy of science during the last quarter century, the number of books by trained philosophers dealing with the logic of biology is surprisingly small. Simon’s book resembles Morton Beckner’s The Biological Way of Thought in its comprehensive ambitions: "trying to discover what, if anything, is distinctive about biological science, its concepts, and its mode of explaining." The most obvious difference of the two books is Simon’s long central chapter on "Theories, Models, and (...) the Concept of the Gene," which deals with the history of genetics from Mendel’s predecessors to the successors of Watson and Crick. Beckner paid little explicit attention to the history of biology. Another difference lies in Beckner’s dogged assessment of all problems in the logic of biology from the perspective of what he called the Humean Pattern of Explanation—a detailed and difficult variant of the approach of Hempel, Oppenheim, and Nagel. Simon’s philosophical position is more flexible than Beckner’s. He provides an acceptable review of the literature of the last decade and a half; some of his conclusions are most interesting—even when incompletely supported by his arguments; and the utility of his book is insured by the fact that it is necessary to go back over twelve years to find another with which it can be compared. The first chapter contains a very effective critique of J. J. C. Smart’s thesis that biology is no more an autonomous science than is electrical engineering, but is merely applied physics and chemistry. Smart had argued from the grounds that all biological generalizations implicitly refer to terrestrial evolution and are not truly universal, and Simon demonstrates the general lack of success of all efforts to demonstrate a difference in kind between so-called laws of nature and empirical generalizations of the sort found in biology. The second chapter continues in this same vein, drawing an interesting contrast between phylogenetic explanation in biology and the explanation of individual events in human history, and claiming that ‘explanatory’ status may be granted to accounts which do not meet the requirements of the deductive-nomological model, as in the case of Darwin’s theories of the geographical distribution of plants and animals and the persistence of rudimentary organs. The author’s negative reaction to much of the recent philosophical literature concerning the role of functional analysis in biology seems particularly well placed. Following Hempel, most philosophers writing in the past ten years have regarded the occurrence of the item whose function is in question as the event to be explained. Simon correctly points out that in the biological literature, statements indicating the presence of this item are part of the explanans, usually one component in an explanation of the normal functioning of the organism. He also insists that functional or teleological statements cannot effectively be replaced by nonteleological ones. A functional account is one that relates an entity to the role it plays in an organized system. In the first of several serene non-sequiturs which mar the latter half of this book, Simon insists that the above account shows that the notion of function is essentially an "extrinsic" one and that teleological principles generally cannot be used to account for experience. No better argument than an appeal to Kant’s authority backs up this conclusion. The third chapter deals with the recent history of genetics; its summary makes the claim that "at no time during this history was it correct to say that one model was replaced by another one; rather, the development appears to have been one involving successive correction and refining of earlier conceptions. There has been no revolution: geneticists have always succeeded in either repelling or accommodating critical attacks on the model." The evidence presented earlier in the chapter confers some plausibility on this conclusion, but no more: Simon takes no notice of the controversy surrounding Kuhn and the notion of scientific revolutions, and provides no criteria by which to distinguish "revolutions" from "accommodations." The precise nature of the methodological continuity to be found in the history of genetics is crucial for the view that "biology, or at least genetics, must be regarded as incapable of yielding a complete explanation of the phenomena that come within its purview; if the ultimate principles appealed to are not those of chemistry and physics and hence essentially nonbiological, the explanation cannot be regarded as complete." The text does not clearly indicate the extent to which the author agrees with the statement just quoted; perhaps he only attributes it to "many biologists" impressed by the successes of molecular genetics. It is clear the Simon regards something he calls the "Cartesian attitude" as pervasive in biology. "Biologists are committed to attempting to explain the phenomena of life in terms of the nonliving... The property of being alive or being associated with a living system is simply not treated as a logical primitive within biological science." But this seems to take us back full circle—to the position of Smart, that biology is no more than applied physics and chemistry. Simon disagrees with Smart. How does he stand vis-a-vis this last statement of the Cartesian spirit he finds so pervasive in biology? I think he disagrees with it, but it is very hard to tell. Perhaps the answer is that the resolution of the issue of the autonomy of biology is a pragmatic matter, relative to a complex set of needs and commitments: the sorts of things that determine life styles, political attitudes, and religious points of view, as well as the growth of scientific understanding. The question of the precise configuration of Simon’s pragmatism remains very vague indeed—a consequence of his over use of the style of impersonal attribution rather than direct assertion. Simon says generally sane and familiar things about Biology and the Idea of Progress and about Biology and Ethics. The really startling assertion of the penultimate chapter, that "consciousness" is neither a biological nor a behavioral predicate, and that its foundations are essentially moral and legal, is unfortunately supported by no argument whatsoever. Instead, the reader is urged to examine two of the author’s previous articles.—E. M. (shrink)

The present book is an interesting essay on Origen's place in the history of Western thought, or better, about the question whether he was a philosopher at all, and if so, in what sense. Because of his intense speculative drive and his wide learning in Neoplatonic thought Origen has been considered to be the "most philosophical" of the Greek Fathers. Such a view very often entails the attempt at "reorganizing" his thought as systematic philosophical reflection. The author's final thesis is (...) that such an approach is doomed to failure in really understanding the Origenian mind. This "pupil" of Ammonius Saccas was above all a Christian theologian and as such an outsider to philosophy. Philosophy had not been taken for granted by him but it was to be probed into from the depth of Christian experience and its theological self-interpretation. Philosophy itself-which means to his mind pagan philosophy—should be treated within the framework of that vast theological enterprise Origen had been carrying through in his whole life. It is only after the analysis of his philosophy of theology that Origen's contribution to philosophy proper can be evaluated. It is in this sense that the author considers his work as a prolegomenon to "Origenian philosophy."—M. J. V. (shrink)

Is well-being the kind of thing that can be summed across individuals? This paper takes a measurement-theoretic approach to answering this question. To make sense of adding well-being, we would need to identify some natural "concatenation" operation on the bearers of well-being that satisfies the axioms of extensive measurement and can therefore be represented by the arithmetic operation of addition. I explore various proposals along these lines, involving the concatenation of segments within lives over time, of entire lives led alongside (...) one another or in sequence, and of evaluatively basic propositions via conjunction. All of these proposals turn out to carry highly controversial commitments about the good. I do not claim that these commitments are unacceptable. But they suggest that we cannot simply take for granted, as many philosophers do, that there is any such thing as the sum of well-being. (shrink)

You may not know me well enough to evaluate me in terms of my moral character, but I take it you believe I can be evaluated: it sounds strange to say that I am indeterminate, neither good nor bad nor intermediate. Yet I argue that the claim that most people are indeterminate is the conclusion of a sound argument—the indeterminacy paradox—with two premises: (1) most people are fragmented (they would behave deplorably in many and admirably in many other situations); (2) (...) fragmentation entails indeterminacy. I support (1) by examining psychological experiments in which most participants behave deplorably (e.g., by maltreating “prisoners” in a simulated prison) or admirably (e.g., by intervening in a simulated theft). I support (2) by arguing that, according to certain plausible conceptions, character evaluations presuppose behavioral consistency (lack of fragmentation). Possible reactions to the paradox include: (a) denying that the experiments are relevant to character; (b) upholding conceptions according to which character evaluations do not presuppose consistency; (c) granting that most people are indeterminate and explaining why it appears otherwise. I defend (c) against (a) and (b). (shrink)

ABSTRACT:This paper examines the norms that should guide policies aimed at promoting happiness or, more broadly, well-being. In particular, we take up the question of which conception of well-being should govern well-being policy, assuming some such policies to be legitimate. In answer, we lay out a case for ‘pragmatic subjectivism’: given widely accepted principles of respect for persons, well-being policy may not assume any view of well-being, subjectivist or objectivist. Rather, it should promote what its intended beneficiaries see as good (...) for them: pleasure for hedonists, excellence for Aristotelians, etc. Specifically, well-being policy should promote citizens’ ‘personal welfare values’: those values—and not mere preferences—that individuals see as bearing on their well-being. Finally, we briefly consider how pragmatic subjectivism works in practice. While our discussion takes for granted the legitimacy of well-being policy, we suggest that pragmatic subjectivism strengthens the case for such policy. (shrink)

With a few notable exceptions disability studies has not taken account of intersexuality, and it is principally through the lenses of feminist and queer-theory oriented ethical discussions but not through ‘straight’ bioethics that modes valuing intersex difference have been proposed. Meanwhile, the medical presupposition that intersex characteristics are inherently disabling to social viability remains the taken-for-granted truth from which clinical practice proceeds. In this paper I argue against bioethical perspectives that justify extensive and invasive pre- and post-natal medical interference to (...) eradicate intersex. I argue instead that to constitute the necessary conditions for the recognition of the intersexed child as a person, a life valid in its own right, clinicians must refrain from aggressive interference. Clinical specialists presuppose that intersexed children will be socially disabled and unrecognizable as persons; frustrated by the general failure of traditional interventions to assign a sex, clinicians are now pursuing prenatal technologies, including selective termination, to erase intersex. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Papirius and the Chickens, or Machiavelli on the Necessity of Interpreting ReligionJohn M. Najemy*No aspect of Machiavelli’s thought elicits a wider range of interpretations than religion, and one may wonder why his utterances on this subject appear to move in so many different directions and cause his readers to see such different things. One reason is of course his famous challenge to conventional piety in the advice to princes (...) (in chapter 18 of The Prince) that, while it is important to appear to be “all compassion, faith, integrity, humanity, and religione, and there is nothing more necessary for a prince than to appear to have the last of these,” these “qualities” can actually be “damaging” if a prince insists on observing them at all times. For it is sometimes necessary to act “against faith, against charity, against humanity, and against religione.” 1 Machiavelli probably never wrote more famous or infamous words than these, even though they express an obvious, and hardly original, truth about all politics. But the world of the later sixteenth- and seventeenth-century reformations and religious absolutisms could not tolerate such honesty, and Machiavelli’s reputation was quickly tarred with accusations of devilish immorality by the very societies that thought it was godly to burn heretics. On the issue of religion Machiavelli became, and to some extent remains, a convenient scapegoat often blamed for the decline of religion in the modern world, all of which has no doubt intensified the polemical and ideological nature of the debates surrounding his views of religion in general and Christianity in particular. [End Page 659]The polar positions in the interpretation of Machiavelli’s ideas about religion are represented by Leo Strauss and Sebastian de Grazia. For Strauss, Machiavelli was a “teacher of evil,” a “blasphemer,” and a purveyor of lessons of a “diabolical” and “soulless character” whose purpose was to sabotage the heritage of thought and morality inherited from both Christianity and Greek philosophy. 2 De Grazia, by contrast, has recently given us a Machiavelli who “discourses about God always in the conventional reverent attitude,” who “never questions that there is good and evil,” and who, “by associating virtuous political action with grace and glory... argues that through this kind of active and political virtue men conform to God’s desire.” “Behind Niccolò’s insistence on political action,” says de Grazia, “stands God. He grants His grace when it is earned—in political coin.” 3 Part of the fascination of Machiavelli scholarship is the mystery of how this most outspoken and direct of political thinkers—a writer who pulled no punches and minced no words—could be the common referent of such wildly different readings. But it is equally curious to observe how uncannily these extreme positions mirror each other. Both give us true believers, one in the Word, the other in the subversion of the Word; and in both cases a believer who is always of a piece, true to himself, and possessed of an unshakeable commitment—whether positive or negative—toward the transcendent truth of Christianity. In short, for all the obvious differences, the similarities between Strauss’s “diabolical” Machiavelli and de Grazia’s reverent “friend of God” remind one of the old myth that devils are after all only fallen angels.The papers in this forum should certainly remove any doubt about the importance of religion in Machiavelli’s thought. They remind us of the prominence of religious language and examples in Machiavelli’s texts: his call for the “redemption” of Italy in the last chapter of The Prince; the esteem in which he holds the heads and founders of religions, whom he declares, in Discourses 1.10, to be the most praised of all famous men; the crucial appeal to the figure of Moses as the prototype of both founders of states and liberators of enslaved peoples; the central role that Machiavelli attributes to religion among the factors responsible for Rome’s power, unity, and political success; and his provocative critique of Christianity, which leads him, in a number of places, to blame the Christian faith for the relative weakness of both modern states and the modern ethic of citizenship. 4 The authors... (shrink)

Effective Field Theory (EFT) is the successful paradigm underlying modern theoretical physics, including the "Core Theory" of the Standard Model of particle physics plus Einstein's general relativity. I will argue that EFT grants us a unique insight: each EFT model comes with a built-in specification of its domain of applicability. Hence, once a model is tested within some domain (of energies and interaction strengths), we can be confident that it will continue to be accurate within that domain. Currently, the Core (...) Theory has been tested in regimes that include all of the energy scales relevant to the physics of everyday life (biology, chemistry, technology, etc.). Therefore, we have reason to be confident that the laws of physics underlying the phenomena of everyday life are completely known. (shrink)

It has long been taken for granted that clinical research involving human subjects is ethical only if it holds out the prospect of producing socially valuable knowledge. Recently, this social value requirement has come under scrutiny, with prominent ethicists arguing that the social value requirement cannot be substantiated as an ethical limit on clinical research, and others attempting to offer new support. In this paper, I argue that both criticisms and existing defenses of the social value requirement are predicated on (...) what I call the “transactional model of stakeholder obligations”. I go on to problematize this framework, and to introduce an alternative framework for conceptualizing ethical obligations within clinical research. In defending this framework, which I call the “basic structure model of stakeholder obligations”, I also demonstrate how it provides a stronger grounding for the social value requirement that is not vulnerable to critiques grounded in the transactional model. (shrink)

This paper is devoted to an examination of the discovery, characterization, and analysis of the functions of microRNAs, which also serves as a vehicle for demonstrating the importance of exploratory experimentation in current (post-genomic) molecular biology. The material on microRNAs is important in its own right: it provides important insight into the extreme complexity of regulatory networks involving components made of DNA, RNA, and protein. These networks play a central role in regulating development of multicellular organisms and illustrate the importance (...) of epigenetic as well as genetic systems in evolution and development. The examination of these matters yields principled arguments for the historicity of the functions of key biological molecules and for the indispensability of exploratory experimentation in contemporary molecular biology as well as some insight into the complex interplay between exploratory experimentation and hypothesis-driven science. This latter result is not only important for philosophy of science, but also of practical importance for the evaluation of grant proposals, although the elaboration of this latter claim must be left for another occasion. (shrink)

The terms ‘compatibilism’ and ‘incompatibilism’ were introduced in the mid-20th century to name conflicting views about the logical relationship between the thesis of determinism and the thesis that someone has free will. These technical terms were originally introduced within a specific research paradigm, the classical analytic paradigm. This paradigm is now in its final stages of degeneration and few free-will theorists still work within it (i.e. using its methods, granting its substantive background assumptions, etc.). This chapter discusses how the ambiguity (...) of the terms ‘incompatibilism’ and ‘compatibilism’ took root as the classical analytic paradigm declined and why this matters to the contemporary debate. Among other things, I explain why the ambiguity of these anachronistic terms, though relatively innocuous when they were first introduced, is now encouraging theorists to tolerate and perpetuate serious philosophical errors (e.g. to conflate relations as different in kind and importance as correlation and causation, to promote uncontentiously invalid arguments, and to equivocate in ways that keep the free-will debate mired in pseudo-stalemates). I also suggest a new framework for anyone looking for relief from the confusion and deadlock created by quixotic attempts to redefine classical narratives and jargon so that they adequately describe the dialectical contours of the contemporary free-will debate. In addition, this new framework allows philosophers to start cross-pollinating work on free will and other famous problems of luck and control, e.g. the paradox of moral luck. (To see the distinctions applied to the philosophical problems of causal luck, constitutive luck, and moral luck, please see my essay "Free Will, Self-Creation, and the Paradox of Moral Luck" (Midwest Studies in Philosophy, 2019). -/- . (shrink)

In the opening sections of this paper, we defined ambiguity in terms of distinct sentences (for a single sentence-string) with, in particular, distinct sets of truth conditions for the corresponding negative sentence-string. Lexical vagueness was defined as equivalent to disjunction, for under conditions of the negation of a sentence-string containing such an expression, all the relevant more specific interpretations of the string had also to be negated. Yet in the case of mixed quantification sentences, the strengthened, more specific, interpretations of (...) some such positive string are not all of them necessarily implied to be false if the corresponding negative sentence-string is asserted. On the contrary, as we saw in section 6, a negative sentence-string can be used to deny one of the more specific interpretations of the corresponding positive string without also denying other weaker interpretations of that same string. One might therefore argue that the only empirical evidence availble for assessing quantified sentences suggests clearly that these sentence-strings are ambiguous. Indeed logicians, many of whom restrict their attention to propositions, MUST recognise logical ambiguity at this point. For the contextualisation of the negative sentences in section 6 showed that it was possible to assert the falsity of some proposition P expressed by the sentence S while asserting a further proposition which was compatible with the truth of S. However the corresponding conclusion that such sentence-strings are sententially ambiguous is not a necessary conclusion for the linguist: for the alternative account of postulating a single semantic representation plus a set of semantic procedures is also compatible with the negation evidence. Moreover we have seen independent reasons for thinking that if sentential ambiguity is assumed to be in one-to-one correspondence with what we should now call logical ambiguity, a considerable body of generalisations is lost. For the maximal ambiguity account, it should be recalled, is committed to assigning at least thirteen distinct propositions and hence thirteen distinct sentence outputs for every sentence-string containing no more than two quantifiers, for three out of the four interpretations originally outlined in this paper can be understood with each numeral taken either in an ’exactly’ sense or in an ’at least’ sense. Moreover there is no explanation of why just these interpretations are available-they are merely an arbitrary list, no more connected than are the two interpretations of John saw her duck, with no reason to predict that the ambiguity would carry over from language to language. If then it is granted that an ambiguity account fails to capture appropriate generalisations, only two alternative accounts of mixed quantification sentence-strings remain viable-an analysis proposing an initial co-ordinate logical form like the logical form III, which is the strongest form compatible with each of the propositional interpretations of sentence-string Two examiners marked six scripts, and the radically weak form in which only existential quantification (both over sets and over members of those sets) is invoked. Since there are strong arguments to suggest that the procedures which both analyses require are semantic, there seems no reason not to adopt the radical vagueness account, with its considerably greater simplicity. (shrink)